| Auburn Tigers vs. Clemson Tigers | Auburn Tigers vs. Clemson Tigers | Georgia Dome | Georgia Dome
Atlanta, GA | 09/01/2012 3:30 AM | Sep 01, 2012 TBA | View Tickets |
| Clemson Tigers vs. Ball State Cardinals | Clemson Tigers vs. Ball State Cardinals | Clemson Memorial Stadium | Clemson Memorial Stadium
Clemson, SC | 09/08/2012 3:30 AM | Sep 08, 2012 TBA | View Tickets |
| Clemson Tigers vs. Furman Paladins | Clemson Tigers vs. Furman Paladins | Clemson Memorial Stadium | Clemson Memorial Stadium
Clemson, SC | 09/15/2012 3:30 AM | Sep 15, 2012 TBA | View Tickets |
| Florida State Seminoles vs. Clemson Tigers | Florida State Seminoles vs. Clemson Tigers | Doak Campbell Stadium | Doak Campbell Stadium
Tallahassee, FL | 09/22/2012 3:30 AM | Sep 22, 2012 TBA | View Tickets |
| Boston College Eagles vs. Clemson Tigers | Boston College Eagles vs. Clemson Tigers | Alumni Stadium | Alumni Stadium
Chestnut Hill, MA | 09/29/2012 3:30 AM | Sep 29, 2012 TBA | View Tickets |
| Clemson Tigers vs. Georgia Tech Yellow Jackets | Clemson Tigers vs. Georgia Tech Yellow Jackets | Clemson Memorial Stadium | Clemson Memorial Stadium
Clemson, SC | 10/06/2012 3:30 AM | Oct 06, 2012 TBA | View Tickets |
| Clemson Tigers vs. Virginia Tech Hokies | Clemson Tigers vs. Virginia Tech Hokies | Clemson Memorial Stadium | Clemson Memorial Stadium
Clemson, SC | 10/20/2012 3:30 AM | Oct 20, 2012 TBA | View Tickets |
| Wake Forest Demon Deacons vs. Clemson Tigers | Wake Forest Demon Deacons vs. Clemson Tigers | BB&T Field (formerly Groves Stadium) | BB&T Field (formerly Groves Stadium)
Winston Salem, NC | 10/25/2012 3:30 AM | Oct 25, 2012 TBA | View Tickets |
| Duke Blue Devils vs. Clemson Tigers | Duke Blue Devils vs. Clemson Tigers | Wallace Wade Stadium | Wallace Wade Stadium
Durham, NC | 11/03/2012 3:30 AM | Nov 03, 2012 TBA | View Tickets |
| Clemson Tigers vs. Maryland Terrapins | Clemson Tigers vs. Maryland Terrapins | Clemson Memorial Stadium | Clemson Memorial Stadium
Clemson, SC | 11/10/2012 3:30 AM | Nov 10, 2012 TBA | View Tickets |
| Clemson Tigers vs. North Carolina State Wolfpack | Clemson Tigers vs. North Carolina State Wolfpack | Clemson Memorial Stadium | Clemson Memorial Stadium
Clemson, SC | 11/17/2012 3:30 AM | Nov 17, 2012 TBA | View Tickets |
| Clemson Tigers vs. South Carolina Gamecocks | Clemson Tigers vs. South Carolina Gamecocks | Clemson Memorial Stadium | Clemson Memorial Stadium
Clemson, SC | 11/24/2012 3:30 AM | Nov 24, 2012 TBA | View Tickets |